When 3:30 PM - 4:10 PM Feb 10, 2006
Where 1504 Dow Connector
Contact Phone 734-763-9425
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Cell-Based Sensors -- Polymer Actuated BioMEMS on CMOS


Elisabeth Smela, University of Maryland
Kay Artico

Cell-based sensors take advantage of the inherent selectivity and sensitivity of biological systems. Such sensors must integrate transduction, actuation, and control for cell handling and long-term culture on the surface of the chip, for controlling the microenvironment by providing nutrients, removing waste, and introducing stimulant, and for receiving and analyzing the signals. System integration efforts for a cell-based “nose” will be described, which entails the microfabrication of polymer-actuated lidded vials on the surface of a CMOS chip, the development of methods for automatically loading the cells into the vials, and the development of various sensors for electrical activity and cell viability.