Geeta Mehta

Associate Professor

mehtagee@umich.edu

3044 NCRC, Building 28

T: (734) 763-3957

Bio

Projects

Publications


Modulation of Hematopoietic Stem Cell activity by Mechanical Stimulation

We are interested in determining if mechanical forces can impact hematopoietic stem cell (HSC) phenotypes. In the body, multipotent HSCs reside predominantly in the marrow cavities of bones in adult mammals and are localized to the osteoblast-lined endosteal niches and the pericyte-lined vascular environments. Bone is a dynamic organ, which responds to mechanical and physiological stimuli. In the bone, the response of osteocytes and osteoblasts to physical forces has been extensively studied. However, other cells within the marrow cavity are also subject to a mechanically active environment. In this project, we will build an in vitro model of the bone marrow that includes the HSCs and bone lining osteoblasts in a hydrogel matrix. In these in vitro engineered bone marrow microenvironments, we will quantify the response of HSCs to changes in the loading or unloading of the bone; as well as, exposure to tensile, compressive, and shear stresses in terms of their frequency, their retention of stem cell renewal potential, and their ability to form differentiated daughters of all lineages. Adult stem cells and animals are used in this laboratory.