Geeta Mehta

Associate Professor

mehtagee@umich.edu

3044 NCRC, Building 28

T: (734) 763-3957

Bio

Projects

Publications


Polymer based Tissue Engineering Models to Study Microenvironmental Control of HER2 Expression in Breast Cancers

Our lab is focused on creation of 3-D microenvironments by using microtechnology and biomaterials as engineering tools. The goal of this project is to develop in vitro systems where the factors of the extracellular matrix that drive metastasis of breast cancer cells can be carefully studied. We are developing polymer/hydrogel based breast cancer tissue engineering platform with precise 3D microscale cytoarchitecture and optimal cell-cell interactions between breast cancer cells and stromal cells (mammary epithelial cells, mesenchymal stem cells, fibroblasts, endothelial cells). This platform will provide 3D model of breast tumor environment that will be used to study and understand how the microenvironment physical properties and the spatial organization of cells and cell-cell interactions regulate expression of oncogenes such as HER2 in breast cancers. Adult stem cells and animals are used in this laboratory.