Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

Geeta Mehta

Associate Professor

mehtagee@umich.edu

3044 NCRC, Building 28

T: (734) 763-3957

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Christopher Moraes, Geeta Mehta, Sasha C Lesher-Perez, and Shuichi Takayama (2012)

ANNALS OF BIOMEDICAL ENGINEERING, 40(6, SI):1211-1227.

Advances in microengineering technologies have enabled a variety ofinsights into biomedical sciences that would not have been possible withconventional techniques. Engineering microenvironments that simulate invivo organ systems may provide critical insight into the cellular basisfor pathophysiologies, development, and homeostasis in various organs,while curtailing the high experimental costs and complexities associatedwith in vivo studies. In this article, we aim to survey recent attemptsto extend tissue-engineered platforms toward simulating organ structureand function, and discuss the various approaches and technologiesutilized in these systems. We specifically focus on microtechnologiesthat exploit phenomena associated with compartmentalization to createmodel culture systems that better represent the in vivo organmicroenvironment.

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