When 3:30 PM - 5:00 PM Sep 12, 2014
Where 1670 Beyster Building
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Biophysics and Dynamics of Bioinspired Materials Systems to Direct Stem Cell Function and Tissue Regeneration

Kevin E. Healy
University of California at Berkeley, Departments of Materials Science and Engineering, and Bioengineering

Highly regulated signals in the stem cell microenvironment such as matrix stiffness, ligand adhesion density, growth factor presentation and concentration, and tissue architecture have been implicated in modulating stem cell differentiation, maturation, and ultimately function. Therefore, it is desirable to have independent control over both the biochemical and mechanical cues presented to cells to analyze their relative and combined effects on stem cell function. Accordingly, we have developed a range of materials systems to study stem cell function. This presentation will discuss our progress in developing bioinspired synthetic hydrogels for transplanted stem cell survival and our more recent work on in vitro disease specific tissue models (e.g., ‘organs on a chip’) to be used for high content drug screening and patient specific medicine.

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