Metal matrix composites have the potential to demonstrate extraordinary properties including, but not limited to, high strength, stiffness, hardness, electrical and thermal conductivity, as well as, low density and coefficient of thermal expansion.  However, they have not had the successes in implementation as their analogous counterparts, polymer-based composites.  Historically, the major hindrances to the widespread adoption of these materials are issues related to design, processing and implementation. This talk seeks to present the challenges and opportunities in metal matrix composite development, as well as, shed new light on the potential of non-traditional methods to metal matrix composite design and fabrication that can lead to composites with unique behaviors. The focus of the talk will illustrate the impact of a thermodynamically-driven, systematic design approach to address and provide solutions for the problems of the past.