This talk will discuss Cima's journey from materials science and engineering to medicine through a series of technologies originating in his lab.  Mostly, it’s a reflection on where these ideas came from. There are three key themes; pivot, adjacency, and theory of change.  Topics will include 1) the role of materials in pharmaceutical development, 2) magnetics in diagnostics, 3) single compartment drug targeting, and 4) hydration status measurement.