Surface Modification of Microfluidic Devices

Joerg Lahann

Professor

lahann@umich.edu

3414 GG Brown

T: (734) 763-7543

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Microfluidic systems are widely used for the separation, detection, and analysis of biochemical reagents. Their miniaturized architecture offers several advantages, such as higher sample throughput and processing rates, low manufacturing costs, advanced system integration, and reduced volumes of samples and analytes. The continuously increasing complexity of microfluidic systems will require the development of methods for the precise and stable fabrication of functional surfaces and controlled spatial surface patterns. Our group uses chemical vapor deposition (CVD) polymerization to deposit reactive coatings on the lumenal surface of PDMS-based microchannels. In addition to being compatible with the requirements of biological assays, these coatings provide a designable interlayer that is stable under the conditions of bioassays. The reactive coatings are based on polymers known as functionalized poly-p-xylylenes (PPXs), which establish interfaces equipped with chemically reactive groups that can be selected from a variety of different chemical species, including amines, alcohols, activated carboxylic acids, and anhydrides. Reactive coatings can be used for immobilization of biomolecules, planar cell and protein patterning, and for patterning of polymer brushes.