Publications

Geeta Mehta

Associate Professor

mehtagee@umich.edu

3044 NCRC, Building 28
T: (734) 763-3957

Bio

Publications


  1. A. Dhyani#, T. Repetto#, D. Bartikofsky, C. Mirabelli, Z. Gao, S. A. Snyder, C. Snyder, G. Mehta, C. E. Wobus, J. S. VanEpps, A. Tuteja, “Surfaces with instant and persistent antimicrobial efficacy against bacteria and SARS-CoV-2”, Matter. 2022 https://doi.org/10.1016/j.matt.2022.08.018 (#equal first-authors)

  2. K. M. A. Yong, E. N. Horst, D. Neale, S. Royzenblat, J. Lahann, C. Greineder, M. Weivoda, G. Mehta, E. T. Keller, “A Bioreactor for 3D In Vitro Modeling of the Mechanical Stimulation of Osteocytes”, Frontiers in Bioengineering and Biotechnology, 2022; 10: 797542. doi: 10.3389/fbioe.2022.797542.PMID: 35402411

  3. E. N. Horst, C. M. Novak, K. Burkhard, C. S. Snyder, R. Verma*, D. E. Crochran*, I. A. Geza*, W. Fermanich*, P. Mehta, D. C. Schlautman*, L. A. Tran*, M. E. Brezenger, and G. Mehta. “Injectable three-dimensional tumor microenvironments to study mechanobiology in ovarian cancer”, Acta Biomaterialia, 2022:S1742-7061(22)00248-3. doi: 10.1016/j.actbio.2022.04.039. PMID: 35487424

  4. A. Kapur, P. Mehta, A. D. Simmons, S. S. Ericksen, G. Mehta, S. P. Palecek, M. Felder, Z. Stenerson, A. Nayak, J. M. A. Dominguez, M. Patankar, L. M. Barroilhet, “Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers”, Cancers (Basel). 2022; 14(9): 2297. https://doi.org/10.3390/ cancers14092297

  5. M. Boban#, P. Mehta#, A. K. Halvey#, T. Repetto#, A. Tuteja, G. Mehta, “Novel Omniphobic Platform for Multicellular Spheroid Generation, Drug Screening, and On-Plate Analysis”, Analytical Chemistry. 2021 93 (22), 8054-8061 DOI: 10.1021/acs.analchem.1c01326 (#equal first-authors)

  6. A. Dhyani, J. Wang, A. K. Halvey, B. Macdonald, G. Mehta, A. Tuteja. “Design and applications of

    surfaces that control the accretion of matter”, Science. 2021, 373(6552):eaba5010. doi: 10.1126/science.aba5010. PMID: 34437123.

  7. E. N. Horst, M. E. Bregenzer, P. Mehta, C. S. Snyder, T. Repetto, Y. Yang-Hartwich, G. Mehta. “Personalized Models of Heterogenous 3D Epithelial Tumor Microenvironments: Ovarian Cancer as a Model”, Acta Biomaterialia. 2021, S1742-7061 (21) 00285-3. doi: 10.1016/j.actbio.2021.04.041. PMID: 33940195

  8. M. S. Chesnokov, I. Khan, Y. Park, J. Ezell, G. Mehta, A. Yousif, L. J. Hong, R. J. Buckanovich, A. Takahashi, I. Chefetz. “The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma”. Cancers (Basel). 2021; 13(6):1369. doi: 10.3390/cancers13061369. PMID: 33803586;

  9. C. M. Novak, E. N. Horst, E. Lin* , G. Mehta, “Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor”, Cancers (Basel). 2020; 12(6):1521. doi: 10.3390/cancers12061521.

  10. S. A. Snyder, M. Boban, C. Li, J. S. VanEpps, G. Mehta, A. Tuteja. “Lysis and direct detection of coliforms on printed paper-based microfluidic devices”. Lab Chip. 2020; 20(23):4413-4419. doi: 10.1039/d0lc00665c. PMID: 329590385

  11. S. Raghavan§, C. S. Snyder§, A. Wang§,*, K. McLean, D. Zamarin, R. Buckanovich, G. Mehta. “Carcinoma-associated mesenchymal stem cells promote chemoresistance and tumorigenicity in ovarian cancer stem cells via PDGF signaling”, Cancers (Basel). 2020; 12, 2063; doi:10.3390/cancers12082063 (§Equal Contribution) 

  12. J. R. Brown, D. Chan, J. J. Shank, K. A. Griffith, H. Fan, R. Szulawski, K. Yang, P. Mehta, M. E. Bregenzer, R. K. Reynolds, C. Johnston, K. McLean, S. Uppal, R. Liu, L. Cabrera, S. E. Taylor, B. C. Orr, F. Modugno, G. Mehta, H. Shen, L. Coffman, R. J. Buckanovich, "A Phase II Translational Clinical Trial of Metformin as a Cancer Stem Cell Targeting Agent in Ovarian, Fallopian Tube, and Primary Peritoneal Cancer”. Journal of Clinical Investigation Insight. 2020; 5(11):e133247. https://doi.org/10.1172/jci.insight.133247.

  13. L. Rivera-Báez, I. Lohse, E. Lin, S. Raghavan, S. Owen, R. Harouaka, K. Herman, G. Mehta, T. S. Lawrence, M. A. Morgan, K. C. Cuneo, S. Nagrath, “Expansion of Circulating Tumor Cells from Patients 3 with Locally-Advanced Pancreatic Cancer Enable Patient Derived Xenografts and Functional Studies for Personalized Medicine”. Cancers (Basel). Special Issue: Liquid Biopsy: Latest Advances and Future Challenges. 2020; 12, 1011.

  14.  

    M. E. Bregenzer§, E. N. Horst§, P. Mehta§, C. M. Novak§, C. S. Snyder§ , T. Repetto, G. Mehta, “Tumor modeling maintains diverse pathology in vitro.” Annals of Translational Medicine. 2019; 7:S262. doi: 10.21037/atm.2019.12.32. (§Equal Contribution)

     

  15. S. Raghavan, P. Mehta, Y. Xie, Y. L. Lei, G. Mehta "Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineering microenvironments". Journal of Immune Therapy of Cancers. 2019; 7(190): 1-15

  16. S. P. R. Kobaku, C. S. Snyder, R. G. Karunakaran, G. Kwon, P. Wong, G. Mehta, A. Tuteja, "Wettability Engendered Templated Self-assembly (WETS) for the Fabrication of Layer-by-Layer Charged, Biocompatible, Multiphasic Particles", ACS Macro Letters. 2019; 8, 11, 1491-1497. https://doi.org/10.1021/acsmacrolett.9b00493

  17.  

    C. M. Novak, E. N. Horst, S. Raghavan, G. Mehta "Upregulation of Cox-2 in MCF7A cells when Exposed to Shear Stress". OBM Genetics. 2019; 3(3):14; doi:10.21926/obm.genet.1903092. 

  18. M. E. Bregenzer§, C. Davis§, E. N. Horst§, P. Mehta§, C. M. Novak§, S. Raghavan§, C. S. Snyder§ , G. Mehta "Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells". Journal of Visualized Experiments. 2019; 149: e59696 (§Equal Contribution)

  19.  

    M. R. W. Rashidi§, P. Mehta§, M. E. Bregenzer§, S. Raghavan§, E. M.-A. Fleck*, E. N. Horst, V. Ravikumar, S. R. Brady, A. H. Bild, A. Rao, R. J. Buckanovich, G. Mehta "Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance". Neoplasia. 2019; 21(8): 822-836 (§Equal Contribution)

  20.  

    C. M. Novak, E. N. Horst, C. Taylor*, C. Liu*, G. Mehta "Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor". Biotechnology and Bioengineering. 2019; doi: 10.1002/bit.27119.: 1-14

  21.  

    M. E. Bregenzer§, E. N. Horst§, P. Mehta§, C. M. Novak§ , G. Mehta "The Role of Mechanical Stimulation and Cancer Stem Cells on Ovarian Cancer Metastasis". Cancers. 2019; 11(1008): 1-21 (§Equal Contribution)

  22.  

    M. E. Bregenzer§, E. N. Horst§, P. Mehta§, C. M. Novak§, S. Raghavan§, C. S. Snyder§ , G. Mehta "Integrated Cancer Tissue Engineering Models for Precision Medicine". PLOS One. 2019; 14(5): e0216564. (§Equal Contribution)

  23.  

    A. R. Dixon, E. N. Horst, J. J. Garcia*, P. R. Ndjouyep-Yamada*, G. Mehta "Morphometric and Computational Assessments to Evaluate Neuron Survival and Maturation within Compartmentalized Microfluidic Devices: The Influence of Design Variation on Diffusion-Driven Nutrient Transport". Neuroscience Letters. 2019; (703): 58-67

  24.  

    I. Menaker-Chefetz, E. Grimley, K. Yang, L. Hong, E. V. Vinogradova, R. Suciu, I. Kovalenko, D. Karnak, C. A. Morgan, M. Chtcherbinine, C. Buchman, B. Huddle, S. Barraza, M. Morgan, K. A. Bernstein, E. Yoon, D. B. Lombard, A. Bild, G. Mehta, I. Romero, C. Y. Chiang, C. Landen, B. Cravatt, T. D. Hurley, S. D. Larsen, R. J. Buckanovich "A Novel Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-Like cells". Cell Reports. 2019; 61(19): 8754-8773

  25.  

    V. Lalone, M. Fawaz, J. Morales-Mercado, M. Mourão, C. S. Snyder, S. Kim, A. Lieberman, A. Tuteja, G. Mehta, T. Standiford, K. Raghavendran, K. Shedden, A. Schwendeman, K. Stringer, G. Rosania6 "Inkjet-Printed Micro- Calibration Standards for Ultraquantitative Raman Spectral Cytometry". Analyst. 2019; (144): 3790-3799

  26.  

    B. C. Huddle, E. Grimley, C. D. Buchman, M. Chtcherbinine, B. Debnath, P. Mehta, K. Yang, C. A. Morgan, S. Li, J. Felton, D. Sun, G. Mehta, N. Neamati, R. J. Buckanovich, T. D. Hurley, S. D. Larsen "Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily- Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy". Journal of Medicinal Chemistry. 2018; 61(19): 8754-8773

  27.  

    C. M. Novak, E. N. Horst, G. Mehta "Mechanotransduction in Ovarian Cancer: Shearing into the Unknown". APL Bioengineering. 2018; 2. (Most downloaded paper of 2018 and 2019) 

  28. O. Shalev, S. Raghavan, J. M. Mazzara, N. Senabulya, P. D. Sinko, E. M.-A. Fleck*, C. Rockwell, N. Simopoulos, C. M. Jones, A. Shwendeman, G. Mehta, R. Clarke, G. E. Amidon, M. Shtein "Printing of small molecular medicines from the vapor phase". Nature Communications. 2017; 8(1): 711

  29.  

    S. Raghavan, P. Mehta, M. R. Ward, M. E. Bregenzer, E. M.-A. Fleck*, R. J. Buckanovich, G. Mehta "Personalized Patterns of Chemoresistance, Tumor Initiation and Tumor Recurrence in Malignant Ascites-derived Ovarian Cancer Stem Cell Spheroids". Clinical Cancer Research. 2017; 23(22): 6934-6945

  30.  

    K. McLean, G. Mehta "Tumor Microenvironment & Models of Ovarian Cancer: Meeting Report from the 2016 11th Biennial Ovarian Cancer Research Symposium". International Journal of Gynecological Cancer. 2017; 27(9S): S2- S9

  31.  

     J. Chien, G. Mehta "Mechanisms of Initiation and Progression of Ovarian Cancers: Meeting Report from the 11th Biennial Ovarian Cancer Research Symposium". International Journal of Gynecological Cancer. 2017; 27(9S Suppl 5): S10-S13

  32.  

    S. Raghavan, P. Mehta, E. N. Horst, M. R. Ward, K. R. Rowley*, G. Mehta "Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity". Oncotarget. 2016; 7(13): 48-61 https://doi.org/10.18632/oncotarget.7659

  33.  

    C. Li, M. Boban, S. A. Snyder, S. P. R. Kobaku, G. Kwon, G. Mehta, A. Tuteja "Paper-Based Surfaces with Extreme Wettabilities for Novel, Open-Channel Microfluidic Devices". Advanced Functional Materials. 2016; 26: 6121-6131

  34.  

    S. Raghavan, M. R. Ward, K. R. Rowley*, R. M. Wold*, S. Takayama, R. J. Buckanovich, G. Mehta "Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays". Gynecologic Oncology. 2015; 138(1): 181-9

  35.  

    A. R. Dixon, S. Rajan, C.-H. Kuo, T. Bersano, R. M. Wold*, N. Futai, S. Takayama, G. Mehta "Microfluidic Device Capable of Medium Recirculation for Non-Adherent Cell Culture". Biomicrofluidics. 2014: 1-14.

  36. Mehta, G, Shiozawa, Y, and Taichman, RS (2013). Hematopoietic Stem Cells and their niches,  Biomaterials and Regenerative Medicine.

  37. Mehta, G, Hsiao, AY, Ingram, M, Luker, GD, and Takayama, S (2012). Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy,  JOURNAL OF CONTROLLED RELEASE, 164(2):192-204.

  38. Moraes, C, Mehta, G, Lesher-Perez, SC, and Takayama, S (2012). Organs-on-a-Chip: A Focus on Compartmentalized Microdevices,  ANNALS OF BIOMEDICAL ENGINEERING, 40(6, SI):1211-1227.

  39. Didwania, M, Didwania, A, Mehta, G, Basak, GW, Yasukawa, S, Takayama, S, de, Rosalia, N, Srivastava, A, and CE (2011). Artificial Hematopoietic Stem Cell Niche: Bioscaffolds to Microfluidics to Mathematical Simulations,  CURRENT TOPICS IN MEDICINAL CHEMISTRY, 11(13):1599-1605.

  40. Williams, CM, Mehta, G, Peyton, SR, Zeiger, AS, Van, VKJ, and Griffith, LG (2011). Autocrine-Controlled Formation and Function of Tissue-Like Aggregates by Primary Hepatocytes in Micropatterned Hydrogel Arrays,  TISSUE ENGINEERING PART A, 17(7-8):1055-1068.

  41. Mehta, G, Williams, CM, Alvarez, L, Lesniewski, M, Kamm, RD, and Griffith, LG (2010). Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels,  BIOMATERIALS, 31(17):4657-4671.

  42. Mehta, G, Lee, J, Cha, W, Tung, Y, Linderman, JJ, and Takayama, S (2009). Hard Top Soft Bottom Microfluidic Devices for Cell Culture and Chemical Analysis,  ANALYTICAL CHEMISTRY, 81(10):3714-3722.

  43. Mehta, K, Mehta, G, Takayama, S, and Linderman, J (2009). Quantitative Inference of Cellular Parameters From Microfluidic Cell Culture Systems,  BIOTECHNOLOGY AND BIOENGINEERING, 103(5):966-974.

  44. Mehta, G, Torisawa, Y, and Takayama, S (2008). Engineering Cellular Microenvironments with MicrofluidicsBiological Applications of Microfluidics:87-114.

  45. Mehta, G, Kiel, MJ, Lee, JW, Kotov, N, Linderman, JJ, and Takayama, S (2007). Automated Formation of Polyelectrolyte Layer Films on PDMS Bioreactor Surfaces for Primary Murine Bone Marrow CultureAdvanced Functional Materials, 17:2701-09.

  46. Mehta, G, Mehta, K, Sud, D, Song, JW, Bersano-Begey, T, Futai, N, Heo, YS, Mycek, M, Linderman, JJ, and Takayama, S (2007). Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture,  BIOMEDICAL MICRODEVICES, 9(2):123-134.

  47. Mehta, G, Drzal, L, Mohanty, A, and Misra, M (2006). Effect of fiber surface treatment on the properties of biocomposites from nonwoven industrial hemp fiber mats and unsaturated polyester resin,  JOURNAL OF APPLIED POLYMER SCIENCE, 99(3):1055-1068.

  48. Mehta, G, Mohanty, AK, Drzal, LT, Kamdem, DP, and Misra, M (2006). Effect of accelerated weathering on biocomposites processed by SMC and compression molding,  JOURNAL OF POLYMERS AND THE ENVIRONMENT, 14(4):359-368.

  49. Sud, D, Mehta, G, Mehta, K, Linderman, J, Takayama, S, and Mycek, M (2006). Optical imaging in microfluidic bioreactors enables oxygen monitoring for continuous cell culture,  JOURNAL OF BIOMEDICAL OPTICS, 11(5).

  50. Bektesevic, S, Beier, J, Chen, L, Eghbali, N, King, S, Levitin, G, Mehta, G, Mullins, R, Reiner, J, Weikel, R, Xie, S, and Gunn, E (2005). Green challenges: student perspectives from the 2004 ACS-PRF Summer,  GREEN CHEMISTRY, 7(6):403-407.

  51. Burgueno, R, Quagliata, M, Mehta, G, Mohanty, A, Misra, M, and Drzal, L (2005). Sustainable cellular biocomposites from natural fibers and unsaturated polyester resin for housing panel applicationsJOURNAL OF POLYMERS AND THE ENVIRONMENT, 13(2):139-149.

  52. Burgueno, R, Quagliata, M, Mohanty, A, Mehta, G, Drzal, L, and Misra, M (2005). Hybrid biofiber-based composites for structural cellular plates,  COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, 36(5):581-593.

  53. Burgueno, R, Quagliata, M, Mohanty, A, Mehta, G, Drzal, L, and Misra, M (2005). Hierarchical cellular designs for load-bearing biocomposite beams and plates,  MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING, 390(1-2):178-187.

  54. Mehta, G, Mohanty, A, Thayer, K, Misra, M, and Drzal, L (2005). Novel biocomposites sheet molding compounds for low cost housing panel applications,  JOURNAL OF POLYMERS AND THE ENVIRONMENT, 13(2):169-175.

  55. Burgueno, R, Quagliata, M, Mohanty, A, Mehta, G, Drzal, L, and Misra, M (2004). Load-bearing natural fiber composite cellular beams and panels,  COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, 35(6):645-656.

  56. Mehta, G, Mohanty, A, Misra, M, and Drzal, L (2004). Biobased resin as a toughening agent for biocomposites,  GREEN CHEMISTRY, 6(5):254-258.

  57. Mehta, G, Mohanty, AK, Misra, M, and Drzal, LT (2004). Effect of Novel Sizing on the Mechanical and Morphological Characteristics of Natural Fiber Reinforced Unsaturated Polyester Resin based Biocomposites,  Journal of Materials Science, 39:2961-2964.